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KMID : 0377519790040010017
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Chung-Ang Journal of Medicine
1979 Volume.4 No. 1 p.17 ~ p.26
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An Experimental Study on Myocardial Depressant Factor in Superior Mesenteric Artery Occlusion Shock
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Park Chan-Young
Cho Sung-Il
Kim Chun
Rhee Sang-Don
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Abstract
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The attempt was made to investigate the presence of myocardial depressant factor in the plasma of rabbits subjected to 2 hours occlusion followed by release of superior mesenteric artery(S.A.O.). The release of SAO caused the severe depression of mean arterial blood presure from 84.7±2.8 mmHg to 32.7±4.5 mmHg. All animals died with in 20-40 minutes after the release. These severe alterations of systemic arterial blood pressure were never observed in sham-operated rabbits. The effect of SAOshocked plasma on the contractility of rabbit papillary muscles from right ventricle was bioassayed in vitro. The isometric contraction of muscle preparations in plasma were triggered by halffield electrical stimulation. The degrees of contractile force in shamoperated plasma were compared with that in SAOshocked plasma. Papillary muscle preparations in 5-20 : 1 diluted SAOshocked plasma showed 21% decrease in the developed peak tension than those in the shamoperated plasma. It was found that the rate of tension development (+dT/dt) was more affected than the time to peack tension. The above results suggest that the decreased myocardial contractility following the release of occlusion of superior mesenteric artery is due to the presence of myocardial depressant factor in the plasma.
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